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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

protease inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ClpP (4) HCV Protease (28) HIV Protease (66) Protease Activated Receptor (PAR) (11) Ser/Thr Protease (36) Virus Protease (34) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (34) Atg4 (2) Aurora Kinase (3) Autophagy (13) Bacterial (7) Beta-lactamase (1) Beta-secretase (2) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Caspase (2) Cathepsin (25) CCR (1) CDK (2) Ceramidase (1) Complement System (3) COX (1) Cytochrome P450 (6) Dengue virus (6) Deubiquitinase (23) Dipeptidyl Peptidase (2) DNA Methyltransferase (1) DNA/RNA Synthesis (7) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (5) EBV (1) Elastase (3) Endogenous Metabolite (10) Enterovirus (2) FAAH (1) Factor Xa (8) Fatty Acid Synthase (FASN) (2) Filovirus (1) Flavivirus (11) Fungal (1) Glucosidase (1) Glutathione Peroxidase (1) HCV (20) HIF/HIF Prolyl-Hydroxylase (1) HIV (51) HMG-CoA Reductase (HMGCR) (1) HPV (1) HSV (3) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (3) Influenza Virus (2) Isotope-Labeled Compounds (17) MALT1 (17) MDM-2/p53 (1) Mitochondrial Metabolism (1) MMP (4) NF-κB (4) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (5) PAI-1 (5) Parasite (10) PKC (1) Proteasome (7) Renin (2) Reverse Transcriptase (1) SARS-CoV (127) Separase (1) Thrombin (7) TNF Receptor (3) Topoisomerase (2) TRP Channel (1) γ-secretase (2)
By Research Areas:	Cancer (119) Cardiovascular Disease (24) Endocrinology (1) Infection (238) Inflammation/Immunology (63) Metabolic Disease (19) Neurological Disease (18)

By Targets:

ClpP (4)

HCV Protease (28)

HIV Protease (66)

Protease Activated Receptor (PAR) (11)

Ser/Thr Protease (36)

Virus Protease (34)

Amyloid-β (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (34)

Atg4 (2)

Aurora Kinase (3)

Autophagy (13)

Bacterial (7)

Beta-lactamase (1)

Beta-secretase (2)

Biochemical Assay Reagents (1)

Carbonic Anhydrase (1)

Caspase (2)

Cathepsin (25)

CCR (1)

CDK (2)

Ceramidase (1)

Complement System (3)

COX (1)

Cytochrome P450 (6)

Dengue virus (6)

Deubiquitinase (23)

Dipeptidyl Peptidase (2)

DNA Methyltransferase (1)

DNA/RNA Synthesis (7)

Drug Metabolite (3)

Drug-Linker Conjugates for ADC (1)

E1/E2/E3 Enzyme (5)

EBV (1)

Elastase (3)

Endogenous Metabolite (10)

Enterovirus (2)

FAAH (1)

Factor Xa (8)

Fatty Acid Synthase (FASN) (2)

Filovirus (1)

Flavivirus (11)

Fungal (1)

Glucosidase (1)

Glutathione Peroxidase (1)

HCV (20)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (51)

HMG-CoA Reductase (HMGCR) (1)

HPV (1)

HSV (3)

IKK (1)

Indoleamine 2,3-Dioxygenase (IDO) (3)

Influenza Virus (2)

Isotope-Labeled Compounds (17)

MALT1 (17)

MDM-2/p53 (1)

Mitochondrial Metabolism (1)

MMP (4)

NF-κB (4)

Nucleoside Antimetabolite/Analog (1)

P-glycoprotein (5)

PAI-1 (5)

Parasite (10)

PKC (1)

Proteasome (7)

Renin (2)

Reverse Transcriptase (1)

SARS-CoV (127)

Separase (1)

Thrombin (7)

TNF Receptor (3)

Topoisomerase (2)

TRP Channel (1)

γ-secretase (2)

By Research Areas:

Cancer (119)

Cardiovascular Disease (24)

Endocrinology (1)

Infection (238)

Inflammation/Immunology (63)

Metabolic Disease (19)

Neurological Disease (18)

403

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cysteine Protease inhibitor 3 Publications Verification	Cathepsin	Others
Cysteine Protease inhibitor is an inhibitor of cysteine protease.

*Cysteine Protease* inhibitor hydrochloride** 3 Publications Verification	Cathepsin	Others
Cysteine Protease inhibitor hydrochloride is an inhibitor of cysteine protease.

*Cysteine protease* inhibitor-3**	Parasite	Infection
Cysteine protease inhibitor-3 (Compound 15) is a Cysteine protease inhibitor. Cysteine protease inhibitor-3 inhibits Pf3D7, PfW2, PfFP2 and PfFP3 with IC₅₀s of 0.74 μM, 1.05 μM, 3.5 μM, and 4.9 μM, respectively. Cysteine protease inhibitor-3 has anti-plasmodial efficacy against both drug-sensitive and drug-resistant parasites .

*Hepatitis Virus C NS3 Protease* Inhibitor 2**	HCV Protease HCV	Infection
Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a K_i of 41 nM .

HIV-1 protease-IN-12	HIV Protease	Infection
HIV-1 protease-IN-12 (compound 35b) is a HIV-1 protease inhibitor with an IC₅₀ of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant .

HIV-1 protease-IN-3	HIV HIV Protease	Infection
HIV-1 protease-IN-3 (compound 14) is a potent inhibitor of HIV-1 protease (IC₅₀=71 nM; EC₅₀=0.86 μM) .

HIV-1 protease-IN-11	HIV Protease	Infection
HIV-1 protease-IN-11 (compound 34a) is a HIV-1 protease inhibitor with an IC₅₀ of 0.41 nM. HIV-1 protease-IN-11 also exhibits significant activity against drug-resistant variant .

TAPI-2 4 Publications Verification TNF protease inhibitor 2	MMP SARS-CoV	Cancer
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

SARS 3CLpro-IN-1	SARS-CoV	Cancer
SARS 3CLpro-IN-1 (Compound 3b) is a SARS 3CL protease inhibitor with an IC₅₀ value of 95 μM, as a specific stereo isomer of the octahydroisochromene scaffold, directs the P1 site imidazole .

(R)-TAPI-2 (R)-TNF protease inhibitor 2	Others	Cancer
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC₅₀ of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .

HIV-1 protease-IN-13	HIV Protease	Infection
HIV-1 protease-IN-13 (compound 18d) is a potent HIV-1 protease inhibitor with an IC₅₀ value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type) .

MK-7845	SARS-CoV	Infection
MK-7845 is a reversible covalent SARS-CoV-2 3CL protease inhibitor with an IC₅₀ of 8.7 nM .

NS2B-NS3pro-IN-1	Virus Protease	Infection
NS2B-NS3pro-IN-1 is a potent inhibitor of Zika Virus NS2B-NS3 protease, with EC₅₀ of 50 μM, that plays an important role in Zika virus (ZIKV) cycle .

SARS-CoV-2-IN-12	SARS-CoV	Infection
SARS-CoV-2-IN-12 (Compound 27) is a potent SARS-CoV-2-related 3C-like protease inhibitor (K_i=32.1 pM) for preventing SARS-CoV-2 viral replication and that could be useful in the research of COVID-19 .

NS2B-NS3pro-IN-2	Virus Protease	Inflammation/Immunology
NS2B-NS3pro-IN-2 (compound 11) is an inhibitor of Zika Virus NS2B-NS3 protease. NS2B-NS3 has antiviral properties at a concentration of 50 μM .

Z-FG-NHO-BzOME	Cathepsin	Infection
Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

JO146	Ser/Thr Protease	Infection
JO146 is a Chlamydia trachomatis high temperature requirement A (CtHtrA) protease inhibitor with IC₅₀s of 21.86 and 1.15 μM for CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibits bacterial infections .

Des(benzylpyridyl) Atazanavir	HIV Protease HIV Drug Metabolite	Infection
Des(benzylpyridyl) Atazanavir (compound M1) is a N-dealkylation product of Atazanavir (HY-17367) metabolite. Atazanavir is a highly selective HIV-1 protease inhibitor. Des(benzylpyridyl) Atazanavir may contribute to the effectiveness Atazanavir but also to the toxicity and interactions. Des(benzylpyridyl) Atazanavir can be used for further research of Atazanavir effects .

TPCK 1 Publications Verification L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK	Ser/Thr Protease HPV	Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium .

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin potently inhibits* serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

Pepstatin 25+ Cited Publications Pepstatin A	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

Pepstatin Trifluoroacetate 25+ Cited Publications Pepstatin A Trifluoroacetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

Pepstatin acetate Pepstatin A acetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease .

Statine (3S,4S)-Statine; (S,S)-Statine	Others	Endocrinology
Statine is an unusual amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.

Pepstatin Ammonium 25+ Cited Publications Pepstatin A Ammonium	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

Leupeptin hemisulfate 25+ Cited Publications	Cathepsin Ser/Thr Protease Virus Protease	Infection Inflammation/Immunology
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin hemisulfate potently inhibits* serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a *protease* inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

DEPN-8	Dengue virus	Infection
DEPN-8 is a WNV protease substrate. DEPN-8 is used for dengue virus protease inhibitor development .

PD 134922	HIV Protease Renin	Infection
PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC₅₀ of 15 nM against HIV-1 protease .

Policresulen	Virus Protease	Infection
Policresulen is a potent inhibitor of DENV2 NS2B/NS3 protease (IC₅₀ of 0.48 μg/mL). Policresulen inhibits DENV2 replication in BHK-21 cells with IC₅₀ of 4.99 μg/mL. Policresulen acts as a competitive inhibitor of the protease, and slightly affects the protease stability .

HIV-1 protease-IN-9	HIV Protease	Infection
HIV-1 protease-IN-9 (compound 5b) is a HIV-1 protease inhibitor, with a K_i of 0.028 nM. HIV-1 protease-IN-9 shows potent antiviral activity, with an IC₅₀ of 66.8 nM .

HIV protease-IN-1	HIV Protease	Infection
HIV protease-IN-1 (compound 1·succinate) is a potent HIV protease non-peptidic inhibitor, can be used to research AIDS .

SP-471	Flavivirus Dengue virus Virus Protease	Infection
SP-471 is a potent dengue virus (DENV) protease inhibitor with IC₅₀ value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV .

PNU-103017	HIV Protease HIV	Infection
PNU-103017 is an HIV protease inhibitor.

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

ONO-3307	Ser/Thr Protease	Cardiovascular Disease
ONO-3307 is a *protease* inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases .

HIV-1 protease-IN-2	HIV Protease	Infection
HIV-1 protease-IN-2 is a potent HIV-1 protease inhibitor with an IC₅₀ of 2.53 nM. HIV-1 protease-IN-2 shows antiviral activity against DRV (Darunavir)-sensitive or DRV-resistant HIV-1 variants .

Saquinavir mesylate 5+ Cited Publications Ro 31-8959/003	HIV HIV Protease Autophagy	Infection Cancer
Saquinavir mesylate is an HIV Protease Inhibitor used in antiretroviral therapy.

HIV-1 protease-IN-5	HIV Protease	Infection
HIV-1 protease-IN-5 (Compound 13c) is a HIV-1 protease inhibitor with an IC₅₀ of 1.64 nM. HIV-1 protease-IN-5 shows remarkable activity against wild-type and DRV-resistant HIV-1 variants .

E 64c 2 Publications Verification
E 64c is a derivative of naturally occurring epoxide inhibitor of cysteine proteases, a Calcium-activated neutral protease (CANP) inhibitor and a very weak irreversible cathepsin C inhibitor. E 64c exhibits entry-blocking effect for MERS-CoV.

Darunavir Ethanolate 5+ Cited Publications TMC114 Ethanolate	HIV HIV Protease	Infection
Darunavir ethanolate (TMC114 Ethanolate) is a potent HIV protease inhibitor used to treat and prevent HIV/AIDS. Darunavir has a K_i of 1 nM for wild type HIV-1 protease.

PCSK9-IN-22	Ser/Thr Protease	Metabolic Disease
PCSK9-IN-22 (compound 29) is an orally active inhibitor of PCSK9. PCSK9-IN-22 inhibits the interaction of the protein with LDLR in vivo .

GRL-190-21	SARS-CoV	Infection
GRL-190-21 (compound 5e) is an inhibitor for SARS-Cov-2-Mpro with a K_i of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC₅₀ of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity .

4-Hydroxy-2-methylbenzenesulfonic acid ammonium	Virus Protease	Infection
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

2-Hydroxy-4-methylbenzenesulphonic acid ammonium	Virus Protease	Infection
2-Hydroxy-4-methylbenzenesulphonic acid ammonium is an impurity of Policresulen. Policresulen is a potent NS2B/NS3 protease inhibitor with an IC₅₀ of 0.48 μg/mL. Policresulen effectively inhibits the replication of DENV2 virus in BHK-21 cells with an IC₅₀ of 4.99 μg/mL. Policresulen acted as a competitive inhibitor of the protease, and slightly affected the protease stability .

Ulinastatin 1 Publications Verification Uristatin	Ser/Thr Protease Apoptosis	Neurological Disease Inflammation/Immunology
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .

Cat. No.	Product Name

HY-L147

Protease Inhibitor Library

604 Compounds compounds

A protease (also called a peptidase, proteinase, or proteolytic enzyme) is an enzyme that catalyzes proteolysis, breaking down proteins into smaller polypeptides or single amino acids, and spurring the formation of new protein products. Proteases play important roles in regulating multiple biological processes in all living organisms, such as regulating the fate, localization, and activity of many proteins, modulating protein-protein interactions, creating new bioactive molecules, contributing to the processing of cellular information, and generating, transducing, and amplifying molecular signals.

Proteases are important targets in drug discovery. Some protease inhibitors are often used as anti-virus drugs and anti-cancer drugs. MCE offers a unique collection of 604 protease inhibitors. MCE Protease Inhibitor Library is critical for drug discovery and development.

HY-L012

Metabolism/Protease Compound Library

4431 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 4431 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

Cat. No.	Product Name	Type

HY-W087937

Benzamidine hydrochloride hydrate 2 Publications Verification Benzenecarboximidamide hydrochloride hydrate	Biochemical Assay Reagents
Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with K_is of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively .

Cat. No.	Product Name	Target	Research Area

HY-W790014

Z-FG-NHO-BzOME

Cathepsin Infection

Z-FG-NHO-BzOME is a cysteine protease inhibitor that selectively inhibits cathepsin B, cathepsin L, cathepsin S, and papain .

HY-P0018

Pepstatin 25+ Cited Publications Pepstatin A	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .

HY-P0018A

Pepstatin Trifluoroacetate 25+ Cited Publications Pepstatin A Trifluoroacetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .

HY-P2502

*Hepatitis Virus C NS3 Protease* Inhibitor 2**	HCV Protease HCV	Infection
Hepatitis Virus C NS3 Protease Inhibitor 2 is a product-based peptide inhibitor of hepatitis C virus (HCV) NS3 protease, with a K_i of 41 nM .

HY-18234

Leupeptin	Ser/Thr Protease Virus Protease Cathepsin	Infection Inflammation/Immunology
Leupeptin is a broad-spectrum, membrane-permeable **protease inhibitor*. Leupeptin potently inhibits* serine, cysteine and threonine proteases. Leupeptin inhibits M ^pro (the main *protease* of SARS-CoV-2) and also has anti-inflammatory activity .

HY-P0018C

Pepstatin acetate Pepstatin A acetate	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease .

HY-P0018B

Pepstatin Ammonium 25+ Cited Publications Pepstatin A Ammonium	HIV Protease Autophagy	Infection Inflammation/Immunology
Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC₅₀s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .

HY-P4243

Dansyl-Glu-Gly-Arg-Chloromethylketone	Ser/Thr Protease	Others
Dansyl-Glu-Gly-Arg-Chloromethylketone is a *protease* inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX .

HY-P2054

Mvt-101	HIV Protease	Infection
Mvt-101 is a hexapeptide-based inhibitor of HIV-1 protease. Mvt-101 is also reduced-peptide-bond inhibitor. Mvt-101 inhibits reproduction of the HIV virus by blocking protease action .

HY-151250

HIV-1 protease-IN-7

HIV Protease Infection

HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC₅₀=3.52 nM, EC₅₀=37 nM) .

HY-P4349

Pyr-Arg-Thr-Lys-Arg-AMC	Peptides	Others
Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-P4349A

Pyr-Arg-Thr-Lys-Arg-AMC TFA	Peptides	Others
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-P1260

FSLLRY-NH2

1 Publications Verification

Protease Activated Receptor (PAR) Neurological Disease

FSLLRY-NH2 is a protease-activated receptor 2 (PAR2) inhibitor .
HY-P4543

HIV-IN petide

HIV HIV Protease Infection

HIV-IN petide is a competitive inhibitor of HIV-1 protease (K_i=50 nM) .
HY-P1260A

FSLLRY-NH2 TFA

1 Publications Verification

Protease Activated Receptor (PAR) Neurological Disease

FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor .
HY-120880

SKF107457

HIV Protease Infection

SKF107457 is an HIV-1 protease inhibitor that can be used in AIDS research .
HY-18234B

Leupeptin Ac-LL

Peptides Metabolic Disease Inflammation/Immunology Cancer

Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity .
HY-P4368

Z-APF-CMK

Peptides Others

Z-APF-CMK is a specific inhibitor of Ca ²⁺-regulated nuclear scaffold protease (CRNSP) .
HY-P1436

Acetyl-pepstatin

HIV Infection

Acetyl-pepstatin is a potent classical inhibitor of aspartic proteases (PRs) with XMRV PR and HIV-1 PR K_i values of 712 nM and 13 nM .
HY-137495

GGACK

PAI-1 Ser/Thr Protease Cancer

GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor .
HY-P2828

[Des-Pro2]-Bradykinin

Peptides Others

[Des-Pro2]-Bradykinin is a protease inhibitor. [Des-Pro2]-Bradykinin prevents the degradation of methionine enkephalin .

HY-122542

PPACK	PAI-1	Cardiovascular Disease
PPACK is a plasminogen activator (rt-PA) inhibitor. PPACK can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK also inhibits the binding of rt-PA to plasma protease inhibitors .

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	Peptides	Cardiovascular Disease
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P1918A

Activated Protein C (390-404), human TFA	Peptides	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a *protease* inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

HY-P5312

Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr	Peptides	Infection
Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a WNV NS2B-NS3 protease substrate. Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is used for WNV NS2B-NS3 protease substrate peptide selective inhibitor development .

HY-P5975

Z-Leu-Leu-Leu-fluoromethyl ketone Z-LLL-FMK	Cathepsin SARS-CoV	Infection
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. Z-Leu-Leu-Leu-fluoromethyl ketone inhibits SARS infection. Z-Leu-Leu-Leu-fluoromethyl ketone also protects mice against a T. crassiceps challenge .

HY-P4040

Ac-D-DGla-LI-Cha-C	HCV Protease	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Ac-D-DGla-LI-Cha-C is a potent HCV protease inhibitor peptide. Ac-D-DGla-LI-Cha-C can be used for the research of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases .

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Peptides	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent Plasmodium subtilisin-like protease 1 (SUB1) inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-149034

Influenza A virus-IN-8 S5	Influenza Virus	Infection
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC₅₀s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a K_d of 1.0 nM .

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name

HY-K0012

Protease Inhibitor Cocktail, Bacteria (EDTA-Free, 100× in DMSO)
MCE Protease Inhibitor Cocktail, Bacteria (EDTA-Free, 100× in DMSO) protects proteins from degradation by endogenous proteases released during protein extraction and purification.

HY-K0010

Protease Inhibitor Cocktail Maximum Cited Publications 978 Publications Verification
Protease inhibitor cocktail is used in cell lysates or tissue extracts to increase protein stability.

HY-K0011

Protease Inhibitor Cocktail, mini-Tablet

185+ Cited Publications

Protease inhibitor cocktail is used in cell lysates or tissue extracts to increase protein stability.

HY-K0013

Protease and Phosphatase Inhibitor Cocktail (EDTA-Free, 10× in ddH2O) 40+ Cited Publications
MCE Protease and Phosphatase Inhibitor Cocktail (EDTA-Free, 10× in ddH2O) protects protein from degradation by endogenous proteases released during protein extraction and purification.

Cat. No.	Product Name	Target	Research Area

HY-P99283

Concizumab NN 7415; mAb 2021; Anti-TFPI Recombinant Antibody	Inhibitory Antibodies	Others
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that binds to the Kunitz-type protease inhibitor (KPI) 2 structural domain of TFPI, thereby blocking the interaction of this structural domain with the FXa active site. Concizumab can be used in the study of haemophilia .

HY-P99050

Sutimlimab	Complement System	Cardiovascular Disease Inflammation/Immunology
Sutimlimab, a first-in-class complement protein component 1, s subcomponent (C1s) inhibitor, can be used for the research of cold agglutinin disease. C1s is a serine protease which cleaves C4 and C2 to form the C3 convertase .

Recombinant Proteins Recommended:

Serpin (Protease Inhibitor)

Species:	Human (18) Mouse (19) Rat (2)
Tag:	His (33) Tag Free (1) GST (1) Fc (4)
Source:	HEK293 (34) Sf9 insect cells (2) P. pastoris (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77199

	Serpin D1 Protein, Human (HEK293, His) Heparin cofactor 2; Heparin cofactor II; HC-II; protease inhibitor leuserpin-2	Human	HEK293
	Serpin D1 protein is a thrombin inhibitor activated by glycosaminoglycans such as heparin or dermatan sulfate. It replaces antithrombin III and becomes the main thrombin inhibitor in the presence of dermatan sulfate. In addition to thrombin inhibition, serpin D1 also has glycosaminoglycan-independent chymotrypsin inhibitory activity. Serpin D1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin D1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin D1 Protein, Human (HEK293, His) is 480 a.a., with molecular weight of ~75-80 kDa.

HY-P71293

	Serpin D1 Protein, Mouse (HEK293, His) Heparin cofactor 2; Heparin cofactor II; HC-II; protease inhibitor leuserpin-2; Serpin D1	Mouse	HEK293
	Serpin D1 is a thrombin inhibitor that is activated by glycosaminoglycans such as heparin or dermatan sulfate. In the presence of dermatan sulfate, HC-II surpasses antithrombin III (AT) as the primary thrombin inhibitor. Serpin D1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin D1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin D1 Protein, Mouse (HEK293, His) is 455 a.a., with molecular weight of 70-90 kDa.

HY-P70316

	Elafin/Trappin-2 Protein, Human (HEK293, His) rHuElafin, His; Elafin; Elastase-Specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; protease inhibitor WAP3; Skin-Derived Antileukoproteinase; SKALP; WAP Four-Disulfide Core Domain Protein 14; PI3; WAP3; WFDC14	Human	HEK293
	Elafin/Trappin-2, a skin-specific inhibitor of neutrophil and pancreatic elastase, safeguards tissues against elastase-mediated proteolysis. Its inhibitory range extends to the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Elafin/Trappin-2 also weakly inhibits Kv11.1/KCNH2/ERG1 and transient receptor potential cation channel subfamily V member 1 (TRPV1), as reported in studies. Elafin/Trappin-2 Protein, Human (HEK293, His) is the recombinant human-derived Elafin/Trappin-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Elafin/Trappin-2 Protein, Human (HEK293, His) is 95 a.a., with molecular weight of 13-15 kDa.

HY-P71294

	Serpin E2 Protein, Mouse (HEK293, His) Glia-derived nexin; GDN; Peptidase inhibitor 7; PI-7; protease nexin 1; PN-1; protease nexin I; Serine protease-inhibitor 4; Serpin E2; Pi7; Pn1; Spi4	Mouse	HEK293
	Serpin E2, a serine protease inhibitor, inhibits thrombin, trypsin, and urokinase, with a notable role in promoting neurite extension by specifically inhibiting thrombin. Its ability to bind heparin underscores interactions with glycosaminoglycans. The multifaceted inhibitory functions of Serpin E2 highlight its significance in regulating serine protease activities and potential impact on cellular processes, particularly in neurodevelopment. Serpin E2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin E2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Serpin E2 Protein, Mouse (HEK293, His) is 378 a.a., with molecular weight of ~48 kDa.

HY-P71301

	Serpin A1c Protein, Mouse (HEK293, His) Alpha-1-antitrypsin 1-3; Alpha-1 protease inhibitor 3; Alpha-1 protease inhibitor 6; Alpha-1-antitrypsin 1-6; Serine protease inhibitor 1-3; Serine protease inhibitor 1-6; Serine protease inhibitor A1c; Serpin A1c; Serpina1c; Dom3; Dom6; Spi1-3; Spi1-6	Mouse	HEK293
	The Serpin A1c protein is a skilled guardian of cellular regulation, specifically acting as an inhibitor of serine proteases, specifically trypsin and chymotrypsin. Its efficacy in blocking enzymatic activity contrasts with its relative ineffectiveness against elastase. Serpin A1c Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A1c protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A1c Protein, Mouse (HEK293, His) is 389 a.a., with molecular weight of 45-60 kDa.

HY-P71294Y

	Serpin E2 Protein, Mouse (HEK293, His, solution) Glia-derived nexin; GDN; Peptidase inhibitor 7; PI-7; protease nexin 1; PN-1; protease nexin I; Serine protease-inhibitor 4; Serpin E2; Pi7; Pn1; Spi4	Mouse	HEK293
	Serpin E2, a serine protease inhibitor, inhibits thrombin, trypsin, and urokinase, with a notable role in promoting neurite extension by specifically inhibiting thrombin. Its ability to bind heparin underscores interactions with glycosaminoglycans. The multifaceted inhibitory functions of Serpin E2 highlight its significance in regulating serine protease activities and potential impact on cellular processes, particularly in neurodevelopment. Serpin E2 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Serpin E2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Serpin E2 Protein, Mouse (HEK293, His, solution) is 378 a.a., with molecular weight of approximately 48 kDa.

HY-P71292

	Serpin A10 Protein, Human (HEK293, His) Protein Z-Dependent protease inhibitor; PZ-Fependent protease inhibitor; PZI; Serpin A10; SERPINA10; ZPI	Human	HEK293
	Serpin A10 protein inhibits coagulation proteases, such as factor Xa, in the presence of PROZ, calcium, and phospholipids. It can also inhibit factor XIa without cofactors. Serpin A10 interacts with PROZ to exert its inhibitory effects on these coagulation factors. Serpin A10 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A10 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A10 Protein, Human (HEK293, His) is 423 a.a., with molecular weight of 55-80 kDa.

HY-P76639

	Serpin A10 Protein, Mouse (HEK293, His) Protein Z-Dependent protease inhibitor; PZ-Fependent protease inhibitor; PZI; Serpin A10; SERPINA10; ZPI	Mouse	HEK293
	Serpin A10 Protein, an inhibitor, regulates by inhibiting the activity of coagulation protease factor Xa in the presence of PROZ, calcium, and phospholipids. It also shows inhibitory effects on factor XIa even without cofactors, highlighting its versatility in modulating key components of the coagulation cascade. Serpin A10 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A10 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A10 Protein, Mouse (HEK293, His) is 427 a.a., with molecular weight of 60-80 kDa.

HY-P70975

	Serpin A5 Protein, Human (HEK293, His) Plasma Serine protease inhibitor; Acrosomal Serine protease inhibitor; Plasminogen Activator inhibitor 3; PAI-3; PAI3; Protein C inhibitor; PCI; Serpin A5; SERPINA5; PCI; PLANH3; PROCI	Human	HEK293
	Plasma serine protease inhibitor (SERPINA5) is a glycoproteins that inhibit serine proteases. SERPINA5 is involved in the regulation of intravascular and extravascular proteolytic activities, controls the sperm motility and fertilization and protect components of the genital tract. SERPINA5 also inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Serpin A5 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A5 Protein, Human (HEK293, His) is 387 a.a., with molecular weight of 44-55 kDa.

HY-P70202

	HAI-2 Protein, Human (HEK293, His) rHuKunitz-type protease inhibitor 2/HAI-2, His; Kunitz-Type protease inhibitor 2; Hepatocyte Growth Factor Activator inhibitor Type 2; HAI-2; Placental Bikunin; SPINT2; HAI2; KOP	Human	HEK293
	HAI-2 protein is a multifunctional inhibitor that regulates multiple cellular processes by potently inhibiting HGFAC and reducing serine protease activity, specifically TMPRSS13 and ST14/matriptase. HAI-2 is good at inhibiting plasmin, plasma and tissue kallikrein, with broad-spectrum inhibitory capabilities. HAI-2 Protein, Human (HEK293, His) is the recombinant human-derived HAI-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HAI-2 Protein, Human (HEK293, His) is 170 a.a., with molecular weight of 24-30 kDa.

HY-P73091

	HAI-1 Protein, Human (His) Kunitz-type protease inhibitor 1; HAI-1; SPINT1; HAI1	Human	HEK293
	HAI-1 Protein serves as an inhibitor of HGFAC, suppressing serine protease activity of ST14/matriptase in vitro and inhibiting TMPRSS13 through the BPTI/Kunitz inhibitor 1 domain. It interacts with HGFAC and TMPRSS13, with the latter interaction promoting TMPRSS13 phosphorylation and cell membrane localization. HAI-1 Protein, Human (His) is the recombinant human-derived HAI-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HAI-1 Protein, Human (His) is 398 a.a., with molecular weight of 50-70 kDa.

HY-P73092

	HAI-1 Protein, Mouse (Fc) Kunitz-type protease inhibitor 1; HAI-1; SPINT1; HAI1	Mouse	HEK293
	The HAI-1 protein is a multifaceted inhibitor that potently inhibits HGFAC and protects against serine proteases such as ST14/matriptase and TMPRSS13. Through its BPTI/Kunitz inhibitor 1 domain, HAI-1 cleverly coordinates inhibition, engaging in a delicate molecular dance with HGFAC and TMPRSS13. HAI-1 Protein, Mouse (Fc) is the recombinant mouse-derived HAI-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HAI-1 Protein, Mouse (Fc) is 414 a.a., with molecular weight of ~73.2 kDa.

HY-P76653

	SPINK2 Protein, Human (HEK293, Fc) Serine protease inhibitor Kazal-type 2; Acrosin-trypsin inhibitor; HUSI-II	Human	HEK293
	SPINK2, a robust acrosin inhibitor, is vital for normal spermiogenesis, preventing premature activation of proacrosin and other proteases to avoid spermiogenesis defects. It likely regulates germ cell apoptosis mediated by serine proteases and displays inhibitory activity against trypsin, indicating involvement in diverse serine protease-dependent processes. SPINK2 Protein, Human (HEK293, Fc) is the recombinant human-derived SPINK2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of SPINK2 Protein, Human (HEK293, Fc) is 61 a.a., with molecular weight of ~33.6-38 kDa.

HY-P76964

	HAI-2 Protein, Mouse (HEK293, His) Kunitz-Type protease inhibitor 2; Placental Bikunin; SPINT2; HAI2; KOP	Mouse	HEK293
	HAI-2 Protein functions as an inhibitor for various proteases, including HGFAC, plasmin, and plasma kallikrein. It also inhibits TMPRSS13 and ST14/matriptase, regulating their serine protease activity. The interaction with TMPRSS13 promotes its phosphorylation and cell membrane localization. HAI-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived HAI-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of HAI-2 Protein, Mouse (HEK293, His) is 113 a.a., with molecular weight of ~19-22 kDa.

HY-P72055

	Serpin A5 Protein, Mouse (Baculovirus, His) Serpina5; Pci; Plasma serine protease inhibitor; Plasminogen activator inhibitor 3; PAI-3; PAI3; Protein C inhibitor; PCI; Serpin A5	Mouse	Sf9 insect cells
	Serpin A5 protein is a heparin-dependent serine protease inhibitor that controls proteolytic activity in body fluids. It binds irreversibly to the serine activation site, inactivating serine proteases and regulating intravascular and extravascular proteolysis. Serpin A5 Protein, Mouse (Baculovirus, His) is the recombinant mouse-derived Serpin A5 protein, expressed by Sf9 insect cells , with N-10*His labeled tag. The total length of Serpin A5 Protein, Mouse (Baculovirus, His) is 381 a.a., with molecular weight of ~45.3 kDa.

HY-P71053

	SPINK1 Protein, Human (HEK293, His) Pancreatic Secretory Trypsin inhibitor; Serine protease inhibitor Kazal-Type 1; Tumor-Associated Trypsin inhibitor; TATI; SPINK1; PSTI	Human	HEK293
	The SPINK1 protein is a serine protease inhibitor that significantly inhibits trypsin, especially in the pancreas, preventing premature activation of the zymogen. This critical role maintains the integrity of pancreatic cellular processes. SPINK1 Protein, Human (HEK293, His) is the recombinant human-derived SPINK1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SPINK1 Protein, Human (HEK293, His) is 56 a.a., with molecular weight of 12-16 kDa.

HY-P702493

	SPINK1 Protein, Mouse (P.pastoris, His) Pancreatic Secretory Trypsin inhibitor; Serine protease inhibitor Kazal-Type 1; Tumor-Associated Trypsin inhibitor; TATI; SPINK1; PSTI	Mouse	P. pastoris
	SPINK1 is a serine protease inhibitor that significantly inhibits trypsin, especially in the pancreas, preventing premature activation of the zymogen. In the male reproductive tract, SPINK1 binds to sperm heads and regulates sperm volume by inhibiting calcium absorption and nitrogen oxide (NO) production. SPINK1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived SPINK1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of SPINK1 Protein, Mouse (P.pastoris, His) is 57 a.a., with molecular weight of 8.1 kDa.

HY-P71085

	Serpin E2 Protein, Human (HEK293, His) Glia-derived Nexin; GDN; Peptidase inhibitor 7; PI-7; protease nexin 1; PN-1; protease nexin I; Serpin E2; SERPINE2; PI7; PN1	Human	HEK293
	Serpin E2 is a serine protease inhibitor that inhibits thrombin, trypsin, and urokinase. Its unique role in promoting neurite extension involves specific inhibition of thrombin activity. Serpin E2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E2 Protein, Human (HEK293, His) is 378 a.a., with molecular weight of ~50.0 kDa.

HY-P71304

	Serpin B12 Protein, Human (HEK293, His) SERPINB12; Serpin B12; Serine protease inhibitor-clade B12	Human	HEK293
	Serpin B12 Protein inhibits trypsin and plasmin, excluding thrombin, coagulation factor Xa, or urokinase-type plasminogen activator. It may have a role in cell differentiation, interacting with SLFN12 in a pathway regulating differentiation, and potentially interacting with USP14. Serpin B12 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin B12 Protein, Human (HEK293, His) is 425 a.a., with molecular weight of ~55.0 kDa.

HY-P77197

	Serpin B12 Protein, Mouse (sf9, His) SERPINB12; Serpin B12; Serine protease inhibitor-clade B12	Mouse	Sf9 insect cells
	Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Serpin B12 Protein, Mouse (sf9, His) is 423 a.a., with molecular weight of ~58 kDa.

HY-P77195

	Serpin A3C Protein, Mouse (HEK293, His) Serine protease inhibitor A3C; Kallikrein-binding protein; KBP; Klkbp	Mouse	HEK293
	Serpin A3C Protein, with its reactive center loop (RCL), guides interactions with target proteases. Binding leads to protease cleavage at the RCL, forming a stable serpin-protease complex, inactivating the protease. Variability in Serpin A3C's RCL sequences among Serpina3 paralogs may influence the specificity of target protease interactions, showcasing the protein's adaptability. Serpin A3C Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A3C protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A3C Protein, Mouse (HEK293, His) is 395 a.a., with molecular weight of 50-60 kDa.

HY-P76084

	SPINK4 Protein, Mouse (HEK293, Fc) Serine protease inhibitor Kazal-Type 4; Peptide PEC-60 Homolog; SPINK4	Mouse	HEK293
	The SPINK4 protein is specifically expressed in the intestine, suggesting a potential role in gastrointestinal physiology. Its local expression implies involvement in digestive system processes, regulation of protease activity, or other functions critical to intestinal homeostasis. SPINK4 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived SPINK4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SPINK4 Protein, Mouse (HEK293, Fc) is 60 a.a., with molecular weight of ~35 kDa.

HY-P76085

	SPINK4 Protein, Mouse (HEK293, His) Serine protease inhibitor Kazal-Type 4; Peptide PEC-60 Homolog; SPINK4	Mouse	HEK293
	The SPINK4 protein acts as a serine-type endopeptidase inhibitor, regulating peptidase activity. It is located in the extracellular region, suggesting that it has inhibitory functions outside the cell. SPINK4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SPINK4 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of SPINK4 Protein, Mouse (HEK293, His) is 60 a.a., with molecular weight of ~8-11 kDa.

HY-P71039

	Serpin I2 Protein, Human (HEK293, His) SERPINI2; Serpin I2; Myoepithelium-derived serine protease inhibitor; Pancreas-specific protein TSA2004; Peptidase inhibitor 14; PI-14; MEPI; PI14;	Human	HEK293
	Serpin I2 Protein, is a member of the serpin (serine protease inhibitor) superfamily. Serpin I2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin. Serpin I2 is downregulated in pancreatic and breast cancer, and associated with acinar cell apoptosis and pancreatic insufficiency when absent in mice. Serpin I2 is associated with refractive error and has the potential for further investigations of the genetic susceptibility to myopia research. Serpin I2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin I2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin I2 Protein, Human (HEK293, His) is 387 a.a., with molecular weight of 44-60 kDa.

HY-P71299

	Vaspin Protein, Human (GST) Serpin A12; OL-64; Visceral Adipose Tissue-Derived Serine protease inhibitor; Vaspin; Visceral Adipose-Specific Serpin; SERPINA12	Human	E. coli
	Vaspin is an adipokine that regulates adipogenesis, metabolism, and inflammation by binding to the chemokine receptors CMKLR1 and CMKLR2. It mainly regulates adipocyte differentiation and affects lipid and glucose metabolism genes. Vaspin Protein, Human (GST) is the recombinant human-derived Vaspin protein, expressed by E. coli , with N-GST labeled tag. The total length of Vaspin Protein, Human (GST) is 394 a.a., with molecular weight of ~72.0 kDa.

HY-P71302

	Serpin A3N Protein, Mouse (HEK293, His) Serine protease inhibitor A3N; Serpin A3N; Serpina3n; Spi2	Mouse	HEK293
	The serpin A3N protein is ubiquitously found in a variety of tissues, showing elevated expression in the brain, heart, liver, lung, spleen, testis, and thymus, implying a variety of physiological functions. In contrast, it shows lower expression in bone marrow, kidney, and skeletal muscle, suggesting a tissue-specific pattern of regulation. Serpin A3N Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin A3N protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin A3N Protein, Mouse (HEK293, His) is 398 a.a., with molecular weight of 57-61 kDa.

HY-P71841

	Serpin A3N Protein, Mouse (P.pastoris, His) Serpina3n; Spi2; Serine protease inhibitor A3N; Serpin A3N	Mouse	P. pastoris
	The serpin A3N protein is ubiquitously found in a variety of tissues, showing elevated expression in the brain, heart, liver, lung, spleen, testis, and thymus, implying a variety of physiological functions. In contrast, it shows lower expression in bone marrow, kidney, and skeletal muscle, suggesting a tissue-specific pattern of regulation. Serpin A3N Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Serpin A3N protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Serpin A3N Protein, Mouse (P.pastoris, His) is 398 a.a., with molecular weight of ~46.8 kDa.

HY-P73654

	Serpin G1 Protein, Rat (HEK293, His) C1IN; C1INH; SERPING1; Serpin G1; Plasma protease C1 inhibitor	Rat	HEK293
	Serpin G1 protein binds complement and inhibits serine-type endopeptidases. It is located in the extracellular space and is involved in aging. Serpin G1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin G1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin G1 Protein, Rat (HEK293, His) is 482 a.a., with molecular weight of ~ 70-95 kDa.

HY-P74558

	Serpin A3N Protein, Rat (HEK293, His) Serpina3n; Spi2; Serine protease inhibitor A3N; Serpin A3N	Rat	HEK293
	The Serpin A3N Protein, belonging to the serpin family, is predominantly expressed in the liver, where it regulates protease activity. As a serine protease inhibitor, Serpin A3N plays a crucial role in modulating enzymatic processes within the liver, highlighting its significance in hepatic functions and maintaining the balance of proteolytic activities in this vital organ. Serpin A3N Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin A3N protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpin A3N Protein, Rat (HEK293, His) is 389 a.a., with molecular weight of 50-65 kDa.

HY-P71297

	Serpin G1 Protein, Mouse (HEK293, His) SERPIN G1; Plasma protease C1 inhibitor; C1 Inh; C1 esterase inhibitor; C1-inhibiting factor; Serping1; C1nh	Mouse	HEK293
	Serpin G1 Protein, also called C1-inhibitor, regulates complement activation, blood coagulation, fibrinolysis, and kinin generation. It forms inactive complexes with C1r or C1s proteases, controlling C1 complex activation. Serpin G1 efficiently inhibits FXIIa and possibly chymotrypsin and kallikrein, and interacts with MASP1. Its inhibitory effects maintain pathway balance, preventing excessive activation and ensuring proper physiological function. Serpin G1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin G1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of Serpin G1 Protein, Mouse (HEK293, His) is 485 a.a., with molecular weight of 92-95 kDa.

HY-P71035

	SPINK4 Protein, Human (60a.a, HEK293, His) Serine protease inhibitor Kazal-Type 4; Peptide PEC-60 Homolog; SPINK4	Human	HEK293
	SPINK4 Protein is a member of the serine protease inhibitors family named Kazal type (SPINK) in humans. SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. SPINK4 can serve as a prognostic marker for colorectal cancer (CRC), bladder cancer (BCa) and Barrett's esophagus. The reduced expression of SPINK4 relates to poor survival in colorectal cancer (CRC). SPINK4 Protein, Human (60a.a, HEK293, His) is the recombinant human-derived SPINK4 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SPINK4 Protein, Human (60a.a, HEK293, His) is 60 a.a., with molecular weight of ~10-13 kDa.

HY-P71300

	Vaspin Protein, Human (HEK293, His) Serpin A12; OL-64; Visceral adipose tissue-derived serine protease inhibitor; Vaspin; Visceral adipose-specific serpin; SERPINA12	Human	HEK293
	Vaspin is an adipokine that regulates adipogenesis, metabolism, and inflammation by binding to the chemokine receptors CMKLR1 and CMKLR2. It mainly regulates adipocyte differentiation and affects lipid and glucose metabolism genes. Vaspin Protein, Human (HEK293, His) is the recombinant human-derived Vaspin protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Vaspin Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-60 kDa.

HY-P73526

	Serpin G1 Protein, Human (500a.a, HEK293, His) C1IN; C1INH; SERPING1; Serpin G1; Plasma protease C1 inhibitor	Human	HEK293
	Serpin G1, also known as C1-inhibitor, controls C1 complex activation by forming a proteolytically inactive complex with C1r or C1s proteases. Its interactions regulate physiological pathways like complement activation, blood coagulation, fibrinolysis, and kinin generation. As a potent inhibitor of FXIIa, chymotrypsin, and kallikrein, Serpin G1 binds to E. coli stcE, protecting against complement-mediated lysis, and engages with MASP1, showcasing its intricate involvement in various cellular processes. Serpin G1 Protein, Human (500a.a, HEK293, His) is the recombinant human-derived Serpin G1 protein, expressed by HEK293, with C-10*His labeled tag. The total length of Serpin G1 Protein, Human (500a.a, HEK293, His) is 478 a.a., with molecular weight of ~110 kDa.

HY-P77484

	Serpina1d Protein, Mouse (HEK293) Alpha-1-antitrypsin 1-4; Serine protease inhibitor 1-4; Serpin A1d; Dom4; Spi1-4	Mouse	HEK293
	The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with tag free. The total length of Serpina1d Protein, Mouse (HEK293) is 413 a.a., with molecular weight of ~54 kDa.

HY-P77485

	Serpina1d Protein, Mouse (HEK293, Fc) Alpha-1-antitrypsin 1-4; Serine protease inhibitor 1-4; Serpin A1d; Dom4; Spi1-4	Mouse	HEK293
	The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Serpina1d Protein, Mouse (HEK293, Fc) is 413 a.a., with molecular weight of 67-77 kDa.

HY-P77486

	Serpina1d Protein, Mouse (HEK293, His) Alpha-1-antitrypsin 1-4; Serine protease inhibitor 1-4; Serpin A1d; Dom4; Spi1-4	Mouse	HEK293
	The Serpina1d protein is a vigilant sentinel in cellular regulation, acting specifically as an inhibitor of serine proteases, particularly trypsin and chymotrypsin. It effectively blocks their enzymatic activity but appears relatively ineffective against elastase. Serpina1d Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpina1d protein, expressed by HEK293 , with C-His labeled tag. The total length of Serpina1d Protein, Mouse (HEK293, His) is 413 a.a., with molecular weight of 45-50 kDa.

HY-P71331

	SPINK7 Protein, Human (HEK293, His) SPINK7; ECRG-2; Esophagus cancer-related gene 2 protein; Serine protease inhibitor Kazal-type 7; ECG2	Human	HEK293
	SPINK7 Protein, a probable serine protease inhibitor, suggests a role in modulating serine protease activity, crucial in diverse biological processes. Its participation likely regulates proteolytic activities, influencing cellular homeostasis and signaling pathways. Further exploration of specific targeted serine proteases and biological contexts will offer insights into SPINK7's role in cellular processes and potential therapeutic applications. SPINK7 Protein, Human (HEK293, His) is the recombinant human-derived SPINK7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SPINK7 Protein, Human (HEK293, His) is 66 a.a., with molecular weight of 11 & 13 kDa, respectively.

HY-P7542

	Serpin A1 Protein, Human (HEK293, His) rHuSerpin A1/alpha-1-Antitrypsin, His; Alpha-1-Antitrypsin; Alpha-1 protease inhibitor; Alpha-1-Antiproteinase; Serpin A1; SERPINA1; AAT; PI	Human	HEK293
	Serpin A1 Protein, Human (HEK293, His) produced in HEK293 cells is a mouse recombinant Serpin A1a with a His tag at the C-terminus. Alpha-1 Antitrypsin Exerts a hepatoprotective effect on immune-mediated hepatitis and acetaminophen-induced liver injury.

HY-P71432

	HE4/WFDC2 Protein, Human (HEK293, His) WAP Four-Disulfide Core Domain Protein 2; Epididymal Secretory Protein E4; Major Epididymis-Specific Protein E4; Putative protease inhibitor WAP5; WFDC2; HE4; WAP5	Human	HEK293
	The HE4/WFDC2 protein is a homotrimeric broad-spectrum protease inhibitor that regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. As a brainstem-restricted receptor, it binds to GDF15 and interacts with RET, activating MAPK and AKT signaling pathways. HE4/WFDC2 Protein, Human (HEK293, His) is the recombinant human-derived HE4/WFDC2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HE4/WFDC2 Protein, Human (HEK293, His) is 94 a.a., with molecular weight of 18-22 kDa.

Cat. No.	Product Name	Chemical Structure

HY-17367S4

Atazanavir-d6

Atazanavir-d₆ is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S3

Atazanavir-d5

Atazanavir-d₅ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S2

Atazanavir-d9

Atazanavir-d₉ is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

HY-17367S

Atazanavir-d15

Atazanavir-d15 is the d₁₅ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .
HY-17367S1

Atazanavir-d18

Atazanavir-d18 is the d₁₈ labled Atazanavir (HY-17367). Atazanavir is a selective HIV-1 protease inhibitor .

HY-10235S

Telaprevir-d4
Telaprevir-d₄ is the deuterium labeled Telaprevir. Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide[1][2][3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity[4].

HY-B0689S

Indinavir-d6

Indinavir-d₆ is the deuterium labeled Indinavir. Indinavir (MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][2][5].

HY-14588S1

Lopinavir-d8
Lopinavir-d₈ (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity[1][2]. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM[3].

HY-17007S

Saquinavir-d9
Saquinavir-d₉ is the deuterium labeled Saquinavir. Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy. Saquinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.36 μM[1][2].

HY-78726S

Fosamprenavir-d4
Fosamprenavir-d₄ is deuterium labeled Fosamprenavir. Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

HY-D0843S

N-Ethylmaleimide-d5
N-Ethylmaleimide-d₅ is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM), a reagent that alkylates free sulfhydryl groups, is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2]. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor[3].

HY-90001S

Ritonavir-d6
Ritonavir-d₆ is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].

HY-14588S

(rel)-Lopinavir-d8

(rel)-Lopinavir-d₈ ((rel)-ABT-378-d₈)is the deuterium labeledLopinavir(HY-14588) . Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with K_is of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity . Lopinavir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 14.2 μM .

HY-90001S1

Ritonavir-13C,d3
Ritonavir- ¹³C,d₃ is the ¹³C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.

HY-17430S1

Amprenavir-d4-1
Amprenavir-d₄-1 is deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM.

HY-17430S

Amprenavir-d4
Amprenavir-d₄ is the deuterium labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.09 μM[1][2].

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat[1]. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2[2][3][4][5].

HY-90001S3

rel-Ritonavir-d6
rel-Ritonavir-d₆ (rel-ABT 538-d₆; rel-RTV-d₆) is the deuterium labeled Ritonavir (HY-90001). Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC₅₀ of 1.61 μM .

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

HY-10237S

Boceprevir-d9
Boceprevir-d₉ is the deuterium labeled Boceprevir. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay[1][2][3][4][5]. Boceprevir inhibits SARS-CoV-2 3CLpro activity[6].

HY-B0372AS

Bromhexine-d3 hydrochloride

Bromhexine-d₃ (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions[1][2][3][4].

Cat. No.	Product Name	Application	Reactivity

HY-P81377

alpha 1-Antitrypsin Antibody (YA1122)

SERPINA1; AAT; PI; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1
IHC-P Human
HY-P82235

SERPING1 Antibody (YA1980)

SERPING1; C1IN; C1NH; Plasma protease C1 inhibitor; C1 Inh; C1Inh; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
WB, IP Human, Mouse, Rat

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